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Leveraging Incretin Hormone Biology for Drug Discovery and Development Noteworthy Successes Noteworthy Failures 5

In T cell activation, glutamine deprivation has been shown to alter the activation of naive CD4 + T cells and result in their differentiation into forkhead box P3-positive (Foxp3 + ) regulatory T (T reg ) cells, which have suppressor functions 109

While both are generally safe, excessive amounts may cause digestive discomfort in some individuals

[6] Other stimulants or anorectics-such as amphetamines, methylphenidate, or decongestants containing ephedrine or pseudoephedrine-can cumulatively elevate cardiovascular risk