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Glutamine (Oral route)

Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high-risk groups are provided in the full prescribing information [see Dosage and Administration (2.1 and 2.4), Contraindications (4), Warnings and Precautions (5.1), Drug Interactions (7), and Use in Specific Populations (8.6, 8.7)]

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When standard, unformulated glutathione is ingested, the highly acidic environment of the stomach (which has a pH of less than 1.5) and the aggressive digestive enzymes (peptidases) in the small intestine rapidly cleave the tripeptide into its three constituent amino acids