is semaglutide safe what about the compounded version FDA has received reports of adverse events after patients used versions of semaglutide. Some compounders may also be using unapproved salt forms. Patients should avoid compounded when an FDA-approved Embody | Personalized GLP-1 Weight

doi: 10.1038/s41594-023-01134-0 28 HeerspinkHJLPerkinsBAFitchettDHHusainMCherneyDZI

Gastrointestinal discomfort and rare allergic reactions are among the possible adverse effects associated with its use

SLC22A12 gene encoding for the urate transporter hURAT1 defects leads to primary renal hypouricemia characterized by increased UA excretion from a reduced reabsorption (Tana et al., 2018)

The conflicting data in some clinical studies may be explained by various factors: [1] most cohort studies lacked individual validation of fractures as primary outcomes, [2] the studies had short follow-up duration and [3] did not consider important risk factors for osteoporosis such as BMD (even though BMD is not a good method for diagnosing osteoporosis in T2DM), and [4] some studies included medications that affect fracture risk, such as corticosteroids or antidepressants