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Third-party tested for research applications only

Before a drug can legally be marketed for a new intended use or indication for use (e.g., new patient population), the safety and efficacy of the new intended use or indication for use must be demonstrated through well-controlled clinical trials

Tumor growth experiments conducted in syngeneic mice inoculated with MC38 cells using PD-1 immune checkpoint inhibitors demonstrated that while BEBT-908 (a dual HDAC/PI3K inhibitor) alone could delay the growth of MC38 tumors, its efficacy was significantly enhanced when combined with anti-PD-1 antibodies, with some host mice surviving for extended periods

L., Nehra, A., Breau, R