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They were housed in separate plastic cages as groups (each cage containing four rats) under standard laboratory conditions, maintaining the temperature between 25 C and humidity between 30% and 70%: a well-ventilated room with a 12-h lightdark cycle (7 a.m.7 p.m.) and unrestricted access to food and water

Listening to your body and adjusting meal size, hydration, and food choices can significantly reduce discomfort

The STEP 5 trial revealed that most participants, particularly adults with obesity or excess mass, achieved considerable and sustained reductions over a 104-week period

This is slightly lower than the reductions reported in RCTs, where HbA1c decreases ranged from -0.5% to -1.8% (ETD of -0.3% to -1.5%), depending on the trial and semaglutide dosage (e.g., STEP, SUSTAIN 5)