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The appropriate concentrations of DHLA and LA to set distinct redox potentials were calculated from the Nernst equation based on the standard reduction potential of lipoic acid ( E LA ) of 290 mV at pH 7.0 (Lees and Whitesides, The redox potential for each of the two redox pairs is defined by the Nernst equation using the respective midpoint potential and ratios ( Q ) of oxidized to reduced roGFP and LA to DHLA, respectively (Equation 2)
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Some endogenous and synthetic antioxidants, such as polyethylene glycol absorbed (PEGSOD), tirilizad (Upjohn), and vitamin E, have been studied for antioxidant effects, but none have shown therapeutic effects (Hawryluk and Bullock, 2015)
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