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Avoid large drinks with meals

Rybelsus is a GLP-1 receptor agonist for type 2 diabetes Both medications require empty stomach administration for optimal absorption and can interfere with each other if taken simultaneously Rybelsus must be taken with no more than 120ml water and requires a 30-minute wait before consuming anything else Semaglutide can increase levothyroxine exposure by approximately 33%, requiring additional thyroid function monitoring Alternative timing involves taking Rybelsus in the morning and levothyroxine at bedtime (34 hours after eating) Regular monitoring of thyroid function tests and HbA1c is essential

Below is a display of the safety results of the adequate and well-controlled studies of RYBELSUS (referred to below as semaglutide tablets) in adult patients with type 2 diabetes mellitus

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