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Research on TfR1 has identified several therapeutic interventions

The results showed that 56.5% of patients with severe LVO stroke who received semaglutide achieved good functional recovery at 90 days, which is similar to the 54.9% in the standard therapy group, indicating comparable efficacy between the two

Even then, not everyone absorbs it well

(Yes, the Nintendo Switch Pro Controller has a D-pad, but the assembled twin-analog controller (comprising the two Joy-Cons) does not.) With the Joy-Cons usable in local multiplayer, Nintendo likely didn't want to give one side an advantage over the other, and/or found making both button interfaces a D-pad to be unworkable (they allow for 8-direction input, instead of a true four buttons, after all)