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FDA-approved based on this and subsequent trials for both type 2 diabetes (Mounjaro) and chronic weight management (Zepbound)

The understanding of this mechanism was later derived from a separate study involving mice.

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Most patients notice the earliest changes during training: steadier output, fewer moments where their legs feel heavier than they should, and a sense that they can stay in the work without dipping into the familiar slump that usually hits halfway through a session