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For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance

Comparing options for actual, evidence-based weight loss If deliberate weight loss is your goal, there are options with stronger trial evidence than B12 injections alone

Vitamin B12 shots are administered most often in those with genetic conditions that block absorption and people with the disorder called pernicious anemia, which can result in severe malabsorption and deficiency

Fifth, the treatment plan including whether oral iron, IV iron, or referral is indicated