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Upon FINO2 treatment, cells exhibit a more extensive oxidized lipid profile, indicating that FINO2 carries out a Fenton reaction with Fe (II), creating alkoxyl radicals that lead to lipid peroxidation (55)

In GD, the major autoantigen (thyroid-stimulating hormone (TSH)-antibody) is to the receptor for the TSH, which causes overproduction of thyroid hormones, resulting in symptoms such as irritability, rapid heartbeat, weight loss, poor tolerance of heat and bulging eyes (Graves orbitopathy) ( Reference Effraimidis and Wiersinga 4 , Reference Marcocci, Kahaly and Krassas 7 , Reference Brent 8 )

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Many topical serums absorb into the upper epidermis without ever reaching the papillary dermis where fibroblasts live