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Thus, various tumors, including glioma, secondary glioblastoma, and acute myeloid leukemia (AML), harboring heterozygous point mutations in the active sites of IDH1/2 show dramatic increases in the R-2-HG levels 111,113,114,115

Structurally related to GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) with alanine substituted for glycine at the N-terminus, AHK-Cu has been studied in cellular biology and biochemical research literature examining copper-binding peptide chemistry, cellular signaling pathways, and tissue research applications

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Serine is a precursor of glycine and cysteine and is involved in methionine and folic acid metabolism, amino acid transportation, DNA/histone methylation and redox balance