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Ozempic works best when combined with a healthy diet and lifestyle habits

Rapid weight loss with GLP1 receptor agonists can come at the cost of skeletal muscle, potentially undermining metabolic and functional outcomes

The consequences of targeting GLP1R across a broad array of cell types highlights a more general principle, that relatively few proteins are expressed in a manner sufficiently selective for optimal drug development

Host-directed anti-mycobacterial activity of colchicine, an anti-gout drug, via strengthened host innate resistance reinforced by the il-1beta/pge(2) axis