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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial

We have seen this happen, and this can be particularly problematic if your kidney function is already lower due to CKD." Patients with advanced CKD (eGFR between 1530 mL/min/1.73 m) or end-stage kidney disease (eGFR below 15 mL/min/1.73 m) require close monitoring since clinical data in these groups is limited

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