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While 100 nM MitoQ only minimally increased DPI-induced cell death ( Figure 1C ), higher MitoQ concentrations significantly enhanced DPI-mediated cell toxicity as measured by an increased PI uptake after 24h, in a MYCN-dependent fashion ( Figure 1E )

162 The study of epigenetic modifications in ACL fibroblasts is another area of molecular biophysics that can provide insights into how genetic and environmental factors influence ligament health

T gel =1.8 (% F127)+1.3 (% F68)+53 An equation is fitted to the data obtained and can be utilized to estimate the Mean Dissolution Time (hr) based on the gelation temperature of F127/F68 mixtures (for 17-25% F127 and 0-10% F68), using results obtained in examples above: MDT= 0.2 ( T gel )+8

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