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Given that cyanide exposure from linamarin is strongly associated with the development of konzo, an increase in plasma oxidative stress may also affect cyanide action or metabolism, potentially amplifying its capacity to induce mitochondrial stress or giving rise to its oxidized form cyanate, which is a strong neurotoxin in various experimental models that can further decrease glutathione levels in the CNS 52,53

The study utilized male Sprague-Dawley rats as their source of tendon fibroblasts

H 2 S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response