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The TgAPParc mouse model, which carries the E693G mutation (APP695) under the control of the murine Thy1.2 promoter, exhibited 3- to 7-fold higher mutant human APP expression compared to endogenous mouse APP

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This reaction produces aldehydes, which then form covalent cross-links between collagen and elastin molecules, strengthening the ECM and providing resistance to mechanical forces [243]