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[64] Dietary recommendations [edit] Some research shows that most people in the United States and the United Kingdom consume sufficient vitamin B 12

In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyl tetrahydrofolate, resulting in functional folate deficiency

This means you can feel the effects of the vitamin B12 shot for up to a month

For individuals with serum vitamin B12 levels below approximately 358.7 pg/mL, targeted vitamin B12 supplementation may help optimize pregnancy outcomes by regulating one-carbon metabolism and mitigating homocysteine-associated toxicity