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The trade-off is that the analogue is a poor model of native IGF-I physiology precisely because it bypasses the buffering system that governs it
Li M, Yang Y, Xiong L, Jiang P, Wang J, Li C
IGF-1 LR3 is not appropriate for patients who are pregnant or breastfeeding, have active cancer or a cancer history (because IGF-1 stimulates cell growth broadly, including potentially malignant cells), have uncontrolled diabetes or diabetic retinopathy, or are under 21
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