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Some researchers hypothesize that maintaining adequate NAD+ levels might support the metabolic improvements initiated by tirzepatide, potentially enhancing insulin sensitivity or supporting weight loss efforts

doi: 10.1177/0003319709333869 80 RodriguesVSMilanskiMFagundesJJTorsoniASAyrizonoMLSNunezCECet al

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A recent study conducted on 41 diabetic patients demonstrated that exposure to the GLP-1 RA dulaglutide over a 48-week period was associated with a substantial decrease in non-butyrate-producing Firmicutes (e.g., Ruminococcus and Blautia ), accompanied by an increase in Bacteroides, Lactobacillus , and Prevotella (74)