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Annual cancer progression risk: 0.6% (1 in 167) Five year risk for either HGD or cancer: 1.5% (1 in 67) Cells may be dysplastic, but the [.text-color-brand-blue][#tip-9]pathologist[#tip-9][.text-color-brand-blue] is not certain In 4% to 8% of biopsies, the presence of dysplasia may be hard to determine with certainty, often because morphological changes associated with less-advanced dysplasia are so small, and may be difficult to distinguish from inflammation