DOI: Published online: May 1, 2025 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea 2 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Corresponding author: Jae Hyun Bae Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea E-mail: [email protected] Copyright 2025 Korean Diabetes Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
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Recombinant human dornase alfa (rhDNase) has been used to break down the excess DNA present within the airway mucus for people with CF and has been somewhat successful at reducing viscoelasticity of mucus and improving clearance, but DNase has not proven beneficial for people with NCFB (Pasteur et al., 2010
These are less common at 2.5 mg but do occur
Peptide-antibody fusion production Anti-PCSK9 antibodies and peptide-antibody fusions were transiently expressed by co-transfection of the heavy and light chain expressing vectors into CHO cells using a polyethylenimine based method 47