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Enhanced cellular polysulfides negatively regulate TLR4 signaling and mitigate lethal endotoxin shock

Mice studies do show that they live longer when given supplemental melatonin over the course of their lives, starting in adulthood.[ref][ref][ref][ref] Animal studies also show that melatonin supplementation (beginning in middle to old age) prevents the decrease in bone mass associated with aging.[ref] It also increases mitochondrial function.[ref] Melatonin is necessary to reap the benefits of exercise when aging.[ref] Supplemental melatonin also doubles insulin sensitivity in older animals.[ref] We dont do human studies on chronic calorie restriction to extend lifespan nor have there been long-term studies in humans on supplemental melatonin for fifty-plus years to know the effect

The standard therapeutic approach uses 0.5 mg daily, ideally split into two doses approximately 12 hours apart

GHK-Cu serums are applied directly to the skin, usually twice daily