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Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC)

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Furthermore, GLP-1 and its analog (Ex-4) enhanced DNA repair and protected cortical neurons in brains of rats after ischemia which were due to up-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) mediated by PI3K/AKT/CREB pathway (100)