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Funding This work has been supported by grants: Zhejiang Shuren University Basic Scientifc Research Special Funds (KXJ1724104C and 2024XZ013), The opening foundation of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine (SKLID2024KF07) and Talent Introduction Project of Zhejiang Shuren University (KXJ1723105)