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Concomitantly, local hypoxia, oxidative stress, and maladaptive ECM remodeling further exacerbate adipocyte dysfunction, underscoring the multifactorial nature of adipose tissue-driven metabolic derangement in T2DM [18]

Obesity and diabetes continue to be two prominent medical issues plaguing society today that seemingly have been met with difficulty finding consensus on long term and practical treatment options

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Exclusion criteria for both cohorts included a type 1 diabetes (T1D) diagnosis, gestational diabetes, metastatic cancer, comorbid conditions related to unintentional weight change, bariatric surgery, pregnancy, and pharmacy claims for anti-obesity medication in the baseline or follow-up periods