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It activates three different metabolic receptors, and two of those, the glucagon receptor and the GIP receptor, do things that go beyond making you eat less
Once-monthly GLP-1 injectables are already in clinical trials, and drugs like retatrutide represent a new generation designed to last longer and work harder
Failing to rotate injection sites can lead to lipodystrophy, an abnormal accumulation or loss of subcutaneous fat at injection sites
The further addition of GCGR agonism in retatrutide introduces Gs-cAMP signalling in hepatocytes, brown adipose tissue, and the central nervous system cell types with limited or no GLP-1R or GIPR expression expanding the tissue scope of the compound's action profile
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