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Oxidative stress was reported to play a vital role in CICI, it occurs due to chemotherapy-induced increased levels of free radicles

5.8.2.4 Platinum salts Nonspecific and specific bronchial hyperresponsiveness in immediate-type asthma caused by platinum salts did not cease after removal from exposure (Merget et al., 1994) (see also section 4.3.4.1)