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Interestingly, a post-hoc analysis of the Prediabetes Lifestyle Intervention Study (PLIS) suggested that patients achieving prediabetes remission differed from non-responders in improvement in whole body insulin sensitivity, visceral adipose tissue (VAT) and intrahepatic fat rather than insulin secretion upon a similar weight loss 76

This leads to a need for increased intake to achieve the same level of reward, resulting in cravings and withdrawal symptoms

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The primary endpointchange in Clinical Dementia Rating Sum of Boxes (CDR-SB)showed no significant difference between groups