81,408 Probenecid Probenecid is a quintessential uricosuric agent with multifaceted effects on renal function, significantly influencing the elimination of organic anions and tubular reabsorption of urate
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114,121 Gastrointestinal autonomic neuropathy Gastrointestinal autonomic neuropathy presents with various symptoms, such as esophageal dysmotility, gastroparesis, and enteropathy, including dysphagia, gastroesophageal reflux, delayed gastric emptying, diarrhea, constipation, and fecal incontinence
5 Unresolved issues and future research directions Despite substantial progress in understanding inter-organellar interactions in PACs, several key aspects remain insufficiently explored