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Cardiovascular benefits of GLP-1 The SELECT trial demonstrated that GLP-1 therapy rapidly reduces heart attacks and strokes. These cardiovascular benefits have long been hinted at in diabetes trials, but the magnitude observed in SELECT surprised even seasoned cardiologists

Retatrutide is a weight loss injection that activates three different hormone receptors in your body: GLP-1, GIP, and glucagon

Jing F, Zou Q, Wang Y, Cai Z, Tang Y (2021) Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation

This is significant for two reasons