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Symptoms of advanced Lyme disease may include: Severe headaches and stiff neck Rash on areas throughout your body Facial palsy (droop) on one or both sides of your face Severe pain and swelling of knees and/or other large joints Pain in bones, joints and soft tissues Irregular heartbeat (Lyme carditis) Dizziness and shortness of breath Brain and spinal cord inflammation Nerve pain Numbness, tingling and shooting pains in the extremities In rare cases, Lyme disease can even cause death