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Fractionation of this sleep-promoting blood eventually yielded a small nine-amino acid peptide that could reproduce these effects, and Monnier and colleagues published their findings in 1977, entering the compound into the scientific literature as Delta Sleep-Inducing Peptide

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Although that study did not explicitly hypothesize to test semaglutide-associated reductions in central adiposity would improve MASLD, its findings support a biologically consistent pathway: reductions in visceral adipose tissue are strongly linked to improvements in hepatic steatosis, systemic inflammation, and metabolic dysfunction in PWH