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In IVDs injected with 10 6 MSCs, the microenvironment and ECM abundance was maintained, whereas the injection of fewer cells (10 5 MSCs) resulted in fewer viable cells and the injection of more cells (10 7 MSCs) resulted in more apoptotic cells [26]

Nevertheless, thymosin-4 has advanced into clinical studies for cardiac repair and corneal wound healing, demonstrating that non-classical signaling peptides can be developed therapeutically when endpoints are well defined