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This active B12 is readily absorbed, aiding in the maintenance of healthy nerve cells, supporting red blood cell formation, and contributing to overall neurological function in the body.*
This may help explain why it is little used by health professionals
It plays a key role in stimulating the release of gonadotropin-releasing hormone (GnRH), which is essential for puberty onset and maintaining reproductive function
It is a biologically active fraction of vitamin B 12 that can be readily taken up by all cells and represents only 6% to 20% of total serum vitamin B 12 .23 In vitamin B 12 deficiency, serum level of holotranscobalamin decreases even before elevation in homocysteine and MMA levels occurs.24 It has been shown that holotranscobalamin is the most sensitive marker for vitamin B 12 deficiency, followed by MMA.23 25 Like homocysteine and MMA, holotranscobalamin cannot be tested in renal patients as its level increases in renal impairment.23 Furthermore, higher cost and lesser availability than homocysteine and MMA testing make it difficult to acquire wide clinical acceptance
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