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Higher levels of CD8 are expressed and secreted by lymphocytes within the thyroid of affected individuals than in peripheral blood mononuclear cells (Itoh et al

indeed, with respect to malaria protection, it has been theorized that protection conferred by G6PD deficiency may be related to increased phagocytosis of parasitized oxidatively-damaged G6PD-deficient RBCs (7779) via binding by macrophage Fc and lectin-like receptors (80), and that such parasites may be more susceptible to ROS (81)

Free Radic Biol Med 52: 22542265

Given the reduced levels of activated HGF and cMet in hepsin / mice, combined with the increased abundance of GJs, we hypothesize that these mice may be more vulnerable to oxidative stress, potentially exacerbating the severity of APAP-induced liver injury