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Yes, when used topically in the right concentration

It was determined that study subjects who were consuming the combo supplement had significantly lower carbon dioxide output, respiratory exchange ratio, heart rate, and blood lactate levels when compared with the placebo group

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Hydroxocobalamin (Vitamin B12) Injection Hydroxocobalamin (Vitamin B12) Injection (10 mL Vial) Product Overview Hydroxocobalamin (Vitamin B12) Injection is a compounded sterile solution of hydroxocobalamin, a form of vitamin B, typically supplied at a concentration of 2 mg/mL in a 10 mL vial