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These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels

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The activation of the JAKSTAT signaling pathway was suppressed by overexpressing aquaporin 1, indicating that aquaporin 1 improves aging and ageassociated dysfunction in TSPC by blocking the JAKSTAT signaling pathway [109]

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