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A combined effect bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] What else are studies showing on GLP-1 RAs: A number of studies are now showing positive effects from GLP-1 that are independent of weight loss

Patients with a BMI of 30, or a BMI of 27 with one weight-related medical condition (like high blood pressure or type 2 diabetes), are candidates for weight loss medications like GLP-1s

They also recently expanded into longevity treatments including NAD+ and sermorelin, though GLP-1 medications remain their bread and butter

[1] Hypoglycemia can occur, particularly when these medications are used in combination with insulin or sulfonylureas