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In conclusion, prolonged IGF-1 diminishes hepatocyte premature senescence to relief liver fibrogenesis via disrupting nuclear p53progerin interaction

That is a large effect and matches the direction of earlier Phase 2 glucose data, but the magnitude is higher than what has been reported in comparable tirzepatide or semaglutide obesity trials

Furthermore, it decreases nitric oxide and IL-1, markers of acne

Silymarin, during clinical trials, shows potential improvements in liver function, reduced mortality rates, and alleviation of symptoms across various liver disorders, with safety assessments showing low adverse effects