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In aged rat models, treatment increased activity of antioxidant enzymes like superoxide dismutase (SOD), glutathione peroxidase, and glutathione-S-transferase, improving overall oxidative defense

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In the heart, cell damage can increase the risk of heart disease

Data from these trials have shown that this treatment when associated with weight loss can reduce emergency department visits and hospital admissions [76], lung function [50, 77, 78], and airway responsiveness [44, 61, 79, 80] in most but not all studies [50], but interestingly this change did not persist in all patients on follow-up [81]