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While the latter one is specifically targeted to pathogens that invade the cytoplasm (38, 39)

Spike protein reduces CFTR protein expression in differentiated airway epithelia To determine if spike-dependent loss of CFTR chloride channel activity might be due to loss of CFTR protein we incubated epithelia with increasing concentrations of Wuhan-Hu-1 [S1S2] spike and -1.351 [S1S2] spike proteins, and quantified total epithelial CFTR protein