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[243] [244] In contrast to human studies, adult female rats exhibit markedly greater dopamine release in the nucleus accumbens and more pronounced behavioral effects from amphetamine administration relative to males, effects that may be modulated by fluctuating estradiol levels across the estrous cycle or more broadly by adult gonadal hormones

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The resulting increased SR calcium load not only explains the positive inotropic effect of cardiac glycosides but also favours spontaneous calcium release and DADs [13, 14]

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