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The element is stored in the body mainly in the kidneys, spleen and testes, as well as in soft tissues, bones and blood, where it can bind to proteins, mainly transferrin

The importance of this antioxidant pathway is illustrated in Nrf2 knockout mice in which lung neutrophil inflammation and pulmonary emphysema were evident as early as 8 weeks after cigarette smoke exposure, whereas wild-type mice showed no lung changes at 16 weeks

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