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DOI: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-41747-9 Online ISBN: 978-3-319-41749-3 eBook Packages: MedicineMedicine (R0) Keywords These keywords were added by machine and not by the authors

In terms of assessing response, the experts indicated that a 1-year trial period was reasonable and that a meaningful response would consist of a qualitative improvement in hunger and/or health-related quality of life (HRQoL) and a reduction of greater than or equal to 5% of body weight in adults or greater than or equal to 5% BMI in pediatric patients

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Glutathione is both an intracellular (in the cell) and extracellular (outside the cell) antioxidant and is involved in DNA synthesis and repair, free radical scavenging, metabolism of toxins and carcinogens, and preventing negative effects of aging