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& Zoghbi, H

PLoS One 2020, 15 (9), No

Although studies have confirmed that GLP-1RAs do have a certain regulatory effect on the proliferation and apoptosis of tumor cells, the application of GLP-1RAs in tumor-related diseases is not currently its main indication, but GLP-1RAs can have a protective effect on the heart, kidney and other organs through their anti-inflammatory, antihypertensive, and lipid-regulating effects

This design directly tested orforglipron ability to serve as a maintenance therapy