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Semaglutide can affect your central nervous system because it can cross the blood-brain barrier to affect areas of the brain involved in appetite regulation and nausea perception, potentially contributing to nausea and even vomiting

Phase 2 clinical data shows a clean linear dose-response relationship, with each dose tier producing approximately 3 additional percentage points of weight loss

In addition, these medications may help to reduce the risk of developing other obesity-related health conditions such as fatty liver disease, sleep apnea, and joint problems

However, some early responders may notice subtle changes relatively quickly