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When muscles contract against resistance, that force stimulates bone remodeling and helps maintain bone density

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The D-Nle~Trp- Ile-NH-(CH 2 )5-CONH 2 analog, which exhibits intermediate inhibition of dimerization, predictably has a moderate affinity for HGF and a moderate ability to inhibit HGF-dependent processes (Figures 25, 26, 27)