Tamamogullari N, Silig Y, Icagasioglu S, Atalay A
In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl-glycoside comprises a sugar linked to a hydrophobic alkyl (e.g., an alkyl comprising about 6 to about 25 carbon atoms) by an amide linkage, an amine linkage, a carbamate linkage, an ether linkage, a thioether linkage, an ester linkage, a thioester linkage, a glycosidic linkage, a thioglycosidic linkage, and/or a ureide linkage
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The retatrutide phase 2 data, showing up to approximately 24.2% mean weight loss at 48 weeks with the 12 mg dose, suggests that the triple agonist mechanism may offer incremental benefit over dual agonism