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Cigarette smoking is related to increase in 2-hydroxylation pathway of E2 and decrease in bio-availability of oestrogen (Reference Michnovicz, Hershcopf and Naganuma40)

PMID: 16801938

Tumor Heterogeneity Lack of response to angiogenesis inhibitors may be explained in terms of the stage of progression, treatment history, and genomic constitution that exist in the tumor microenvironment (Relf et al., 1997)

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